文献类型：期刊文献

英文题名：One-Health Challenge in H9N2 Avian Influenza: Novel Human-Avian Reassortment Virus in Guangdong Province, China

作者：Yao, Qiucheng[1];Liu, Jing[1];Liu, Huizhen[1];Zhou, Yan[1];Huo, Miaotong[1];Li, Yuanguo[2];Gao, Yuwei[2];Ge, Ye[1]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang, Peoples R China;[2]Acad Mil Med Sci, Mil Vet Res Inst, Changchun, Peoples R China

年份：2024

卷号：2024

外文期刊名：TRANSBOUNDARY AND EMERGING DISEASES

收录：SCI-EXPANDED(收录号：WOS:001168749500001)、、Scopus(收录号：2-s2.0-85203862571)、WOS

基金：We thank the authors and laboratories that submitted sequences of AIVs to the GISAID and NCBI databases. This work was supported by the Natural Resource Affairs (Ecological Forestry Construction) Project of the Guangdong Forestry Department (grant number K23051), the Innovation and Strengthening Project of Guangdong Ocean University (grant number 230419067), and a Ph.D. start-up grant (grant number 521202292).

语种：英文

外文摘要：China is one of the highest producers of poultry meat output in the world, with a large scale of chicken rearing. Statistically analyzed H9N2-subtype avian influenza viruses (AIVs) have become the dominant subtype in China's live poultry market, with the highest detection rate. Although H9N2 AIV is of low pathogenicity and tends not to cause serious disease and high mortality in poultry, it poses a great challenge to the domestic poultry farming industry by causing a decrease in appetite, a decline in egg production, and deaths caused by mixed infections with another pathogenic microorganism. Moreover, novel influenza viruses (H7N9 and H3N8) infecting humans have emerged in China, and the H9N2 AIV provides all or part of the internal genes to the new recombinant viruses, posing a potential threat to public health and safety and human health. In this research, six H9N2 AIVs were isolated from feces or oropharyngeal swabs collected from live poultry markets and duck farms in Zhanjiang. After epidemiological investigations, phylogenetic analyses, and molecular characterization, we found that the ZJ81 strain was a chicken-human-mink recombinant virus, the ML3 strain was a chicken-human recombinant virus, and all six virus strains of the virus had a bias for the human receptor-binding site and a mutation that could cause an increase in virulence in mice. Therefore, surveillance and control of H9N2 AIV should be strengthened to provide data support for cross-species transmission of H9N2 AIV.