文献类型：期刊文献

中文题名：AA鸡禽流感母源抗体和免疫抗体消长变化的研究

英文题名：Study on Growth and Decline Changes of Maternal Antibody and Immune Antibody of AA Chicken Avian Influenza

作者：徐春厚[1];谢为天[1];王硕[1];谭结宁[1];曾敏[1]

机构：[1]广东海洋大学动物医学系

年份：2008

卷号：36

期号：30

起止页码：13163

中文期刊名：安徽农业科学

外文期刊名：Journal of Anhui Agricultural Sciences

收录：北大核心2004、北大核心

基金：湛江市重大科技计划项目(B04071)

语种：中文

中文关键词：AA鸡;禽流感;母源抗体;免疫抗体;消长变化

外文关键词：AA chicken; Avian influenza; Maternal antibody; Immune antibedy; Growth and decline changes

中文摘要：[目的]为AA鸡的禽流感预防提供依据。[方法]用不同剂量的2种禽流感疫苗免疫8日龄AA鸡,通过血凝抑制（HI）试验研究AA鸡禽流感母源抗体和免疫抗体的消长变化。[结果]AA鸡禽流感母源抗体在1～7日龄时缓慢下降,之后迅速下降,表明其半衰期约为2 d。2种禽流感疫苗均可用于AA鸡的预防接种,免疫后15 d,免疫抗体HI效价达到保护临界值,20 d时达到峰值,然后缓慢下降,43日龄时仍在临界值以上。2种不同剂量的禽流感灭活油乳剂疫苗接种后所产生的HI抗体效价的峰值差异极显著。[结论]选用禽流感灭活油乳剂疫苗,免疫剂量为0.5 ml/只,免疫时间为8日龄,整个饲养期免疫1次,即可预防商品代AA鸡禽流感。

外文摘要：[ Objective] The study was to provide the basis for preventing AA chicken avian influenza. [Method] The 8-day old AA chicken were immunized by 2 kinds of avian influenza vaccines with different doses, andthe growth and decline changes of matemal antibody and immtme antibody of AA Chicken avian influenza was studied through bemagglutination inhibition（HI）test. [ Result ] The maternal antibody of AA Chicken avian influenza was decreased gradually when the chicken was 1-7 days old and then it was decreased rapidly, which indicated that the half-life of the maternal antibody was about 2 d. 2 kinds of avian influenza vaccines all could be used for preventive inoculation on AA chicken. After the chickens were simmtmized for15 d, the titer of immune antibody HI reached the protection critical value, and it reached the peak value on the 20th d after immunization, then it was decreased gradually, but it was still above the critical value when the chickens were 43 days old. The difference of the peak values of HI antibody titer produced by vaccination with 2 kinds of avian influenza inaetvaed oil-emulsion vaccines with different dosages was obviously significant. [ Conclusion] The avian influenza in commcrcial AA chickens could be prcvenled under Ihc condition of sciccing avian influenza inactvaetl oil-cmulsion vaccine with dosage of 0.5ml/chicken, immune time for the chicken at 8 day old of and immuning 1 time in whole feeding period.