文献类型：期刊文献

英文题名：Chitosan-collagen composite biomaterials: Advances and insights into properties and biomedical applications

作者：Huang, Jinhong[1];Dong, Hongrui[1];Li, Lefan[1];Kong, Lingxue[2];Hu, Zhang[1]

机构：[1]Guangdong Ocean Univ, Fac Chem & Environm Sci, Zhanjiang 524088, Peoples R China;[2]Deakin Univ, Inst Frontier Mat, Geelong, Vic 3216, Australia

年份：2025

卷号：320

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:001554564800003)、、EI(收录号：20252918808398)、Scopus(收录号：2-s2.0-105010966159)、WOS

基金：The authors acknowledge the financial support of Guangdong Provincial Natural Science Foundation of China (2024A1515012618) , Key Projects of Colleges and Universities in Guangdong Province (2022ZDZX2027) , Guangdong Ocean University Undergraduate Inno-vation Team Project (CXTD2021020) , and National Key Research and Development Program of China (2020YFD0901101) for this work.

语种：英文

外文关键词：Chitosan; Collagen; Chitosan-collagen composites; Biomaterials; Biological properties; Applications

外文摘要：Chitosan polysaccharides and collagen, derived from natural products, are important macromolecular compounds with extensive applications in many fields. In the past decade, substantial progress has been made in studying chitosan-collagen (CS-Col) composite biomaterials. Based on the morphology of materials, this work systematically reviews CS-Col composite biomaterials including nanoparticles, nanofibers, hydrogels, threedimensional (3D) bioprinting scaffolds, films, and sponges. CS-Col composite biomaterials possess a range of unique properties including biocompatibility, antibacterial, antioxidant, hemostatic effects, promoting wound healing, and immune regulation. This review also summarizes advances in the applications of CS-Col composite biomaterials in medical fields, and provides insights into the challenges on future developments, as well as the prospects with the frontier technologies (e.g., 4D bioprinting, artificial intelligence-driven material design).