文献类型：期刊文献

英文题名：Whole-genome resequencing reveals the selection of adaptive evolution during the domestication of pearl oyster Pinctada maxima

作者：Zhang, Teng[1];Zhang, Jiawei[1];Yang, Chuangye[1,2,3,4];Zheng, Zhe[1];Liao, Yongshan[5];Mkuye, Robert[1];Hou, Yongkang[1];Liang, Minxin[1];Fu, Shirong[1];Wang, Ping[1];Zhong, Shijie[1];Wang, Qingheng[1,2,3,4,5];Deng, Yuewen[1,2,3,4,5]

机构：[1]Guangdong Ocean Univ, Fisheries Coll, Zhanjiang 524088, Peoples R China;[2]Guangdong Sci & Innovat Ctr Pearl Culture, Zhanjiang 524088, Peoples R China;[3]Pearl Breeding & Proc Engn Technol Res Ctr Guangdo, Zhanjiang 524088, Peoples R China;[4]Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Zhanjiang 524088, Peoples R China;[5]Guangdong Ocean Univ, Pearl Res Inst, Zhanjiang, Peoples R China

年份：2025

卷号：55

外文期刊名：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS

收录：SCI-EXPANDED(收录号：WOS:001488946000001)、、Scopus(收录号：2-s2.0-105001313846)、WOS

基金：This work was supported by Department of Education of Guangdong Province (Grant No. 2024ZDZX4061 and 2021KCXTD026) , Guangdong Basic and Applied Basic Research Foundation (Grant No. 2023A1515011769) , National Key Research and Development Program of China (Grant No. 2022YFD2401303) , the Fund of the Key Laboratory of Tropical Marine Ecosystem and Bioresource, MNR (Grant No. 2021QN08) , and the earmarked fund for CARS-49.

语种：英文

外文关键词：Pinctada maxima; Domesticated stock; Whole genome resequencing; Adaptive evolutionary event

外文摘要：The aquatic environment has a major effect on the domestication of species for aquaculture in nearshore environments. Disruptions in the ion composition of marine ecosystems have a major effect on the growth and development of aquaculture populations. However, research on the adaptation of domesticated bivalves to nearshore environments and the potential underlying regulatory mechanisms is limited. Here, we collected domesticated offspring (F1 and F2) and wild individuals (F0 and Pw) of Pinctada maxima from nearshore areas. We performed a comprehensive genomic data analysis using whole-genome resequencing data. This comprehensive analysis facilitated the identification of signatures of selection on key genes and yielded locus information associated with critical adaptive evolutionary (AE) events during the domestication process. We also evaluated genetic diversity metrics, including observed heterozygosity (Ho), expected heterozygosity (He), and the Fixation index (Fis). The findings indicated that domesticated P. maxima may experience balancing selection. In the second-generation domesticated stock, we identified 372 candidate selection regions and 624 genes. Local AE events in the domesticated offspring populations were confirmed via quantitative polymerase chain reaction. We proposed a potential compensatory mechanism in which calcium ions for the main effector genes calmodulin (PmCaM) and catabolite activator protein (PmCAP) are cyclically cached. Our findings enhance our understanding of the mechanisms underlying the regulation of calcium ions, which is essential for the adaptation of species to variation in environmental conditions.