文献类型：期刊文献

英文题名：Ginsenosides from Panax ginseng as potential therapeutic candidates for the treatment of inflammatory bowel disease

作者：Niu, Zhiqiang[1];Liu, Yanan[1];Shen, Ruyi[1];Jiang, Xiaojian[2];Wang, Yanting[1];He, Ziliang[1];Li, Junyao[1];Hu, Yeye[1];Zhang, Ji[2];Jiang, Yunyao[4];Hu, Weicheng[1];Si, Chuanling[5];Wei, Shuai[3];Shen, Ting[1]

机构：[1]Yangzhou Univ, Inst Translat Med, Sch Med, Yangzhou 225009, Peoples R China;[2]Huaiyin Normal Univ, Sch Life Sci, Huaian 223300, Peoples R China;[3]Guangdong Ocean Univ, Coll Food Sci & Technol, Zhanjiang 524088, Peoples R China;[4]Tsinghua Univ, Inst Chinese Mat Med, Sch Pharmaceut Sci, Beijing 100084, Peoples R China;[5]Tianjin Univ Sci & Technol, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China

年份：2024

卷号：127

外文期刊名：PHYTOMEDICINE

收录：SCI-EXPANDED(收录号：WOS:001207405700001)、、WOS

基金：Acknowledgments This study was financially supported by Hainan Province Science and Technology Special Fund (ZDYF2024XDNY177) , National Naturalr Science Foundation of China (31700304) and the Basic Science (Natural Science) Research Foundation of Jiangsu Higher Education Institutions of China (23KJA550001) .

语种：英文

外文关键词：ginsenoside; IBD; Cellular immunity; Intestinal barrier; NLRP3 inflammasome

外文摘要：Background: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the intestine, which significantly affects patients' quality of life. As a perennial plant with the homology of medicine and food, Panax ginseng is known for its substantial anti-inflammatory effects in various inflammatory disorders. Ginsenosides, the main bioactive compounds of P. ginseng, are recognized for their efficacy in ameliorating inflammation. Purpose: Over the past decade, approximately 150 studies have investigated the effects of P. ginseng and ginsenosides on IBD treatment and new issues have arisen. However, there has yet to be a comprehensive review assessing the potential roles of ginsenosides in IBD therapy. Method: This manuscript strictly adheres to the PRISMA guidelines, thereby guaranteeing systematic synthesis of data. The research articles referenced were sourced from major scientific databases, including Google Scholar, PubMed, and Web of Science. The search strategy employed keywords such as "ginsenoside", "IBD", "colitis", "UC", "inflammation", "gut microbiota", and "intestinal barrier". For image creation, Figdraw 2.0 was methodically employed. Results: Treatment with various ginsenosides markedly alleviated clinical IBD symptoms. These compounds have been observed to restore intestinal epithelia, modulate cellular immunity, regulate gut microbiota, and suppress inflammatory signaling pathways. Conclusion: An increasing body of research supports the potential of ginsenosides in treating IBD. Ginsenosides have emerged as promising therapeutic agents for IBD, attributed to their remarkable efficacy, safety, and absence of side effects. Nevertheless, their limited bioavailability presents a substantial challenge. Thus, efforts to enhance the bioavailability of ginsenosides represent a crucial and promising direction for future IBD research.