文献类型：期刊文献

英文题名：PAYCS Alleviates Scopolamine-Induced Memory Deficits in Mice by Reducing Oxidative and Inflammatory Stress and Modulation of Gut Microbiota-Fecal Metabolites-Brain Neurotransmitter Axis

作者：Zhao, Tiantian[1,2];Zhong, Saiyi[2];Xu, Jucai[3];Jiao, Wenjuan[1];Liu, Weifeng[1];Huang, Lihua[4];Zhang, Yehui[1];Zhang, Yousheng[1]

机构：[1]Guangdong Acad Agr Sci, Sericulture & Agri Food Res Inst, Key Lab Funct Foods, Minist Agr & Rural Affairs,Guangdong Key Lab Agr, Guangzhou 510610, Peoples R China;[2]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[3]Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China;[4]Guangzhou City Polytech, Dept Food, Guangzhou 510405, Peoples R China

年份：2022

卷号：70

期号：9

起止页码：2864

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：SCI-EXPANDED(收录号：WOS:000767891600008)、、EI(收录号：20220911729689)、Scopus(收录号：2-s2.0-85125414495)、WOS

基金：This research was financially supported by the Natural Science Foundation of Guangdong Province (nos. 2020A1515010659 and 2018B0303110006) and open fund of Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Ocean University (GDPKLAPPS2002), the Excellent Doctoral Talents Introduction Project of Guangdong Academy of Agricultural Sciences (R2021YJ-YB3006), Guangdong Foreign Cooperation Project (2018A050506048), and Guangdong MEPP Fund [2019]A38.

语种：英文

外文关键词：peptides; scopolamine; gut microbiota; fecal metabolites; brain neurotransmitters

外文摘要：The bioactive peptide PAYCS (Pro-Ala-Tyr-Cys-Ser) identified from anchovy hydrolysates has been reported to be positive in memory alleviation. The gut microbiota-brain axis plays a vital role in brain functions, which could be affected by nutritional supplementation. Herein, we found that PAYCS at different concentrations (PAYCS-L and PAYCS-H) showed various improving effects in behavioral tests and alleviation effects on oxidative as well as inflammatory stress in the scopolamine-induced AD mouse model. The 16S rRNA results illustrated that PAYCS-L altered the ratio of Bacteroidetes/Firmicutes and PAYCS treatment elevated the relative abundance of Cacteroidaceae and Prevotellaceae. Notably, administration of PAYCS significantly upregulated memory-related metabolites and neurotransmitters. Overall, PAYCS-L reversed memory deficits of amnesiac mice partially via the modulation of gut microbiota-metabolites-brain neurotransmitter axis. For PAYCS-H, functions might be involved in the reversal of oxidative and inflammatory impairments in the liver and serum, which was also associated with the changed intestinal microbiota and fecal metabolites.