文献类型：期刊文献

中文题名：马氏珠母贝糖胺聚糖毒理学安全评价

英文题名：Toxicity Evaluation of Glycosaminoglycan from Pinctada martensii

作者：范秀萍[1];吴红棉[1];叶庆俊[1];钟敏[1];胡雪琼[1];雷晓凌[1]

机构：[1]广东海洋大学食品科技学院,广东湛江524006

年份：2013

卷号：34

期号：1

起止页码：295

中文期刊名：食品科学

外文期刊名：Food Science

收录：CSTPCD、、北大核心2011、Scopus、北大核心、CSCD、CSCD2013_2014

基金：广东省科技厅科技计划项目(2005B204012)

语种：中文

中文关键词：珠母贝糖胺聚糖;急性毒性;遗传毒性;30d喂养实验

外文关键词：glycosaminoglycan from Pinctada martensii （CPG）; acute toxicity; genotoxicity; subchronic oral toxicity

中文摘要：目的:研究珠母贝糖胺聚糖作为保健食品使用的毒理学安全性。方法:利用大鼠急性毒性实验、小鼠骨髓细胞微核实验、小鼠精子畸变实验、Ames实验和大鼠30d喂养实验进行毒理学研究与评价。结果:急性毒性实验结果表明珠母贝糖胺聚糖对雌、雄大鼠急性经口最大耐受量(MTD)均大于20.0g/kg,其剂量大于人体推荐量的300倍,说明受试物属于无毒级物质。小鼠骨髓细胞微核实验、小鼠精子畸变实验、Ames实验3项遗传毒性实验的结果皆为阴性,未显示出致突变性。30d喂养实验表明,珠母贝糖胺聚糖高、中、低3个剂量组(分别为2.5、1.25、0.625g/kg)动物的身体、脏器的生长发育及血液生化指标等均无明显不良影响。结论:珠母贝糖胺聚糖具有较好的安全性,可作为保健食品使用。

外文摘要：Objective： To evaluate the toxicological safety of glycosaminoglycan from Pinctada martensii （CPG） as a health food. Methods： Rat acute toxicity test, mouse bone marrow cell micronucleus test, mouse sperm aberration test, Ames test and 30-day rat feeding test were used. Results： Acute toxicity test showed that the acute oral maximum tolerated doses （MTD） of CPG to male and female rats were both more than 20.0 g/kg body weight, which were over 300 times higher than the recommended human dose, indicating that CPG was non-toxic. The results of genotoxicity tests, including mouse bone marrow cell micronucleus test, mouse sperm aberration test and Ames test, were all negative and without mutations. In addition, no obvious negative impact on body weight, the growth and development of visceral organs or blood biochemical indicators was observed during 30 days of feeding at doses of 2.50, 1.25 g/kg and 0.625 g/kg body weight. Conclusion： It is safe to eat CPG as a dietary supplement.