文献类型：期刊文献

中文题名：海洋生物中砷脂形态分析及毒性评价研究进展

英文题名：A Review of Speciation Analysis and Toxicity Evaluation of Arsenolipids in Marine Organisms

作者：陈佳佳[1,2];钟映雄[1,2];周雪巍[1];李瑞[1,2];陈建平[1,2];刘晓菲[1,2];贾学静[1,2];宋兵兵[1,2];钟赛意[1,2,3]

机构：[1]广东海洋大学食品科技学院,广东省水产品加工与安全重点实验室,广东省海洋生物制品工程实验室,广东省海洋食品工程技术研究中心,广东湛江524088;[2]广东海洋大学深圳研究院,广东深圳518108;[3]大连工业大学海洋食品精深加工关键技术省部共建协同创新中心,辽宁大连116034

年份：2023

卷号：44

期号：1

起止页码：277

中文期刊名：食品科学

外文期刊名：Food Science

收录：CSTPCD、、EI(收录号：20230513466795)、Scopus、CSCD2023_2024、北大核心、CSCD、北大核心2020

基金：国家自然科学基金面上项目(31972163);“十三五”国家重点研发计划项目(2020YFD0901101);广东省重点领域研发计划项目(2020B1111030004);广东省高校科技创新团队项目(2021KCXTD021)。

语种：中文

中文关键词：海洋生物;砷脂;形态分析;毒性评价

外文关键词：marine organisms;arsenolipids;speciation analysis;toxicity evaluation

中文摘要：砷是一种有毒类金属,已被确定为人类致癌物,砷中毒会造成人体多种健康问题。砷可以分为无机砷和有机砷,一般认为无机砷毒性大于有机砷。砷脂属于有机砷,广泛存在于海洋生物组织中。之前的研究认为砷脂毒性极低,但近年来随着科学技术的进步与发展,对砷脂的研究越来越深入,砷脂的形态分析和毒性评价也逐步成为热点。目前已知的砷脂主要包括含砷脂肪酸、含砷碳氢化合物和含砷磷脂3种形态,且不同形态之间毒性各不相同。但由于其形态结构复杂、生物利用度低、含量低以及提取和检测难度高等原因,砷脂毒性作用机制尚不明确。因此,本文综述了海洋生物中砷脂主要形态的分析方法和毒性评价的最新研究进展,以期为进一步阐明砷脂的形态、毒性以及对人类健康的风险评估提供参考。

外文摘要：Arsenic is a poisonous semi-metal(metalloid)and has been identified as a human carcinogen.Arsenic poisoning can cause a variety of health damage to the human body.Arsenic can exist in both inorganic and organic forms.It is generally considered that inorganic arsenic is more toxic than organic arsenic.Arsenolipids are organic arsenic and widely exist in tissues of marine organisms.Arseniolipids have been previously thought to be extremely low toxic.With the progress and development of science and technology in recent years,intensive research has been conducted on arsenolipids,and the speciation analysis and toxicity evaluation of arsenolipids have gradually become a hot spot.At present,there are three known species of arsenolipids,namely arsenic-containing fatty acids(AsFAs),arsenic-containing hydrocarbons(AsHCs)and arsenic-containing phospholipids(AsPLs),which differ in their toxicity.However,due to the complex speciation pattern,low bioavailability and low content of arsenolipids,and the difficulty to extract and detect them,the mechanism of arsenolipid toxicity remain unclear.Therefore,this paper reviews the latest progress in the methods for speciation analysis and toxicity evaluation of arsenolipids in marine organisms,with the aim to provide an inspiration for further elucidating the speciation,toxicity,and human health risk of arsenolipids.