文献类型：期刊文献

英文题名：Interleukin-8 involved in Nile Tilapia (Oreochromis niloticus) against bacterial infection

作者：Li, Xing[1];Jiang, Baijian[1];Zhang, Zhiqiang[1];Huang, Meiling[1];Feng, Jiamin[1];Huang, Yongxiong[1];Amoah, Kwaku[1];Huang, Yu[1,2,3];Jian, Jichang[1,2,3]

机构：[1]Guangdong Ocean Univ, Key Lab Control Dis Aquat Anim Guangdong Higher Ed, Guangdong Prov Key Lab Aquat Anim Dis Control & Hl, Coll Fishery,Southern Marine Sci & Engn Guangdong, Zhanjiang, Peoples R China;[2]Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China;[3]Guangdong Prov Engn Res Ctr Aquat Anim Hlth Assess, Shenzhen, Peoples R China

年份：2023

卷号：141

外文期刊名：FISH & SHELLFISH IMMUNOLOGY

收录：SCI-EXPANDED(收录号：WOS:001063211800001)、、WOS

基金：This research was funded by National Natural Science Foundation of China (No. 32002426, 32073006).

语种：英文

外文关键词：Interleukin 8; Nile tilapia; Bacterial infection; Acute inflammation

外文摘要：Interleukin 8 (IL8) is vital in promoting inflammation and is a crucial mediator in various physiopathological processes while influencing immunological function. The effect of IL8 on the immunological response to acute bacterial infections in Nile tilapia (Oreochromis niloticus) remains unknown. This work found an IL8 gene from Nile tilapia (On-IL8). It includes a 285 bp open reading frame and codes for 94 amino acids. The transcript levels of On-IL8 were highest in the head-kidney tissue and sharply induced by Streptococcus agalactiae and Aeromonas hydrophila. Besides, in vitro experiments revealed that On-IL8 regulated a variety of immunological processes and promoted inflammatory responses. Moreover, On-IL8 suppressed the NF-& kappa;B signaling pathway, consistent with in vitro results. These significant findings serve as the basis for further investigation into how IL8 confers protection to bony fish in opposition to bacterial infections.