文献类型：期刊文献

中文题名：盐酸氯苯胍在美国红鱼体内的药代动力学和残留消除规律研究

英文题名：Analysis of Pharmacokinetics and Residues Elimination Regularity of Robenidine Hydrochloride in Sciaenops ocellatus

作者：汤菊芬[1,2];黄瑜[1,2];蔡佳[1,2];廖建萌[3];黄月雄[1,2];简纪常[1,2]

机构：[1]广东海洋大学水产学院,湛江524088;[2]广东省水产经济动物病原生物学及流行病学重点实验室,湛江524088;[3]广东省湛江市质量计量监督检测所,湛江524022

年份：2017

卷号：36

期号：6

起止页码：2399

中文期刊名：基因组学与应用生物学

外文期刊名：Genomics and Applied Biology

收录：CSTPCD、、北大核心2014、CSCD2017_2018、北大核心、CSCD

基金：农业部公益性行业专项(20120385);广东省科技计划(农村科技领域)项目(2015A020209181)共同资助

语种：中文

中文关键词：盐酸氯苯胍;美国红鱼;药代动力学;残留消除

外文关键词：Robenidine hydrochloride, Sciaenops ocellatus, Pharmacokinetics, Residues

中文摘要：在水温(28±2)℃、盐度28条件下,盐酸氯苯胍(robenidine hydrochloride,ROBH)按30 mg/kg的剂量口灌实验鱼,用HPLC-MS/MS法研究盐酸氯苯胍在美国红鱼体内的药代动力学和残留消除规律。结果显示,单剂量口灌给药后,美国红鱼血浆中ROBH的药时数据符合一级吸收二室模型,药物在血浆中的达峰时间(tp)、血药浓度峰值(Cmax)、药时曲线下面积(AUC_(0-∞))和消除半衰期(t_(1/2β))分别为2.39 h、958.78μg/L、33 247.57μg/(L·h)和19.24 h;ROBH在肌肉、肝脏和肾脏的Cmax分别为156.72μg/kg、227.68μg/kg和553.44μg/kg,tp分别为2.0 h、1.5 h、2.0 h;AUC_(0-∞)分别4 664.04μg/(kg·h)、4 897.74μg/(kg·h)、17 228.19μg/(kg·h);t_(1/2β)分别为19.68 h、24.33 h和22.81 h。按30 mg/kg剂量连续5 d口灌给药后,美国红鱼肌肉、肝脏、肾脏中的药物消除半衰期(t1/2):24.46 h、35.39 h、39.60 h和33.94 h。若以10μg/kg为最高残留限量,肌肉作为食用靶组织,在本试验条件下,建议休药期不少于7 d。

外文摘要：The pharmacokinetics and residues elimination regularity of robenidine hydrochloride （ROBH） in plasma and tissues of Sciaenops ocellatus were investigated by orally administrated ROBH into Sciaenops ocellatus with a single dose of 30 mg/kg at the water temperature of （28±2）℃ and salinity of 28 by HPLC-MS/MS method. Results showed that ROBH drug-time data in plasma of S. ocellatus was fitted to a two compartment model with first order absorption after single oral dosing. The peak time （tp）, the maximum concentration （Cmax）, the area under the concentration-time curve （A UC0-∞） and the elimination half-life （t1/2β） of plasma were 2.39 h, 958.78 μg/L, 33 247.57 μg/（L·h） and 19.24 h, respectively. The Cmax of ROBH in muscle, liver and kidney were 156.72 μg/kg, 227.68 μg/kg and 553.44μg/kg, tp were 2.0 h, 1.5 h and 2.0 h, A UC0-∞ were 4 664.04 μg/（kg·h）, 4 897.74 μg/（kg ·h） and 17 228.19 μg/（kg ·h）, t1/2β were 19.68 h, 24.33 h and 22.81 h, respectively. The t1/2 of ROBH in plasma, muscle, liver and kidney were 24.46 h, 35.39 h, 39.60 h and 33.94 h after S. ocellatus wastreated with continuous oral administration with 30 mg/kg dose for 5 days. If the maximum residue limits （MRLs） were set as 10 μg/kg and the muscles were regarded as edible target tissue, the withdrawl period should be no less than 7 days under this experiment condition.