文献类型：期刊文献

中文题名：氮杂环改性壳聚糖-碘复合物的制备及抗菌活性

英文题名：Preparation and antibacterial activity of N-heterocyclic modified chitosan-iodine complex

作者：翁博雅[1];贺怡心[1];陈丽红[1];黄美茹[1];程瑜[1];胡章[1]

机构：[1]广东海洋大学化学与环境学院应用化学系,广东湛江524088

年份：2023

卷号：52

期号：7

起止页码：1979

中文期刊名：应用化工

外文期刊名：Applied Chemical Industry

收录：CSTPCD、、CSCD_E2023_2024、北大核心、CSCD、北大核心2020

基金：国家重点研发计划项目(2020YFD0901101);广东省普通高校重点项目(2022ZDZX2027);广东省大学生创新创业训练计划项目(S202210566071);广东海洋大学本科生创新团队项目(CXTD2021020)。

语种：中文

中文关键词：壳聚糖;化学改性;氮杂环;复合物;抗菌活性

外文关键词：chitosan;chemical modification;N-heterocycle;complex;antibacterial activity

中文摘要：通过亲核加成-消除反应,壳聚糖与氮杂环吡啶醛形成亚胺结构,随后在静电引力作用下,与碘络合,制备氮杂环改性壳聚糖-碘复合物;采用紫外光谱、傅里叶变换红外光谱和X-射线衍射等对产物进行结构表征。所有结果证实,氮杂环改性壳聚糖-碘复合物已成功制备。体外抗菌结果显示,氮杂环改性壳聚糖-碘复合物对金黄色葡萄球菌和大肠杆菌的抑菌圈分别为(26.2±0.3)mm和(19.8±0.3)mm,具有较强的抗菌活性。因此,氮杂环改性壳聚糖-碘复合物有望开发为海洋生物医用抗菌敷料。

外文摘要：N-Heterocyclic modified chitosan-iodine complex was prepared with chitosan through the mechanism of nucleophilic addition-elimination reaction to form imine with N-heterocyclic pyridinal,and then complexing with iodine under electrostatic attraction.The structure of the product was characterized by ultraviolet-visiable spectroscopy(UV-Vis),fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD).All the results demonstrated that the N-heterocycle modified chitosan-iodine complex has been successfully prepared.The results of antibacterial activity in vitro showed that N-heterocyclic modified chitosan-iodine complex had strong antibacterial activities,and the inhibition zones of against Staphylococcus aureus and Escherichia coli were(26.2±0.3)mm and(19.8±0.3)mm,respectively.Therefore,N-heterocyclic modified chitosan iodine complex is expected to be developed as marine biological medical antibacterial dressing.