文献类型：期刊文献

英文题名：Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides

作者：Yao, Wanzi[2,3];Qiu, Hua-Mai[2,3];Cheong, Kit-Leong[1,2];Zhong, Saiyi[1]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang, Peoples R China;[2]Shantou Univ, Guangdong Prov Key Lab Marine Biotechnol, STU UNIVPM Joint Algal Res Ctr, Dept Biol,Coll Sci, Shantou 515063, Guangdong, Peoples R China;[3]South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

年份：2022

卷号：221

起止页码：472

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：SCI-EXPANDED(收录号：WOS:000864524500005)、、EI(收录号：20240815592570)、Scopus(收录号：2-s2.0-85137631950)、WOS

基金：This work was supported in part by Key -Area Research and Devel- opment Program of Guangdong Province (2020B1111030004) , The Innovative Team Program of High Education of Guangdong Province (2021KCXTD021) , and Special Project of Guangdong Science and Technology Department (210718205862114) .

语种：英文

外文关键词：Polysaccharides; Marine algae; Anti -cancer; Mechanisms; Signalling pathways

外文摘要：Cancer is a leading cause of death in both developing and developed countries. With the increase in the average global life expectancy, it has become a major health problem and burden for most public healthcare systems worldwide. Due to the fewer side effects of natural compounds than of chemotherapeutic drugs, increasing scientific attention is being focused on the development of anti-cancer drugs derived from natural sources. Marine algae are an interesting source of functional compounds with diverse health-promoting activities. Among these compounds, polysaccharides have attracted considerable interest for many years because of their excellent anti-cancer abilities. They improve the efficacy of conventional chemotherapeutic drugs with relatively low toxicity to normal human cells. However, there are few reviews summarising the unique anti-cancer effects and underlying mechanisms of marine algae polysaccharides (MAPs). Thus, the current review focuses on updating the advances in the discovery and evaluation of MAPs with anti-cancer properties and the elucidation of their mechanisms of action, including the signalling pathways involved. This review aims to provide a deeper un-derstanding of the anti-cancer functions of the natural compounds derived from medicinal marine algae and thereby offer a new perspective on cancer prevention and therapy with high effectiveness and safety.