文献类型：期刊文献

英文题名：Effect of chitosan on blood profile, inflammatory cytokines by activating TLR4/NF-κB signaling pathway in intestine of heat stressed mice

作者：Mohyuddin, Sahar Ghulam[1,2];Qamar, Aftab[1];Hu, Can-Ying[1];Chen, Sheng-Wei[2];Wen, Jia-Ying[2];Liu, Xiao-Xi[2];Ma, Xing-Bin[2];Yu, Zhi-Chao[2];Yong, Yan-Hong[2];Wu, Lian-Yun[1];Bao, Ming-Long[2];Ju, Xiang Hong[2,3]

机构：[1]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept Anim Sci, Zhanjiang 524088, Guangdong, Peoples R China;[2]Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518018, Peoples R China;[3]Guangdong Ocean Univ, Coll Coastal Agr Sci, Dept OfVet Med, Zhanjiang 524088, Guangdong, Peoples R China

年份：2021

卷号：11

期号：1

外文期刊名：SCIENTIFIC REPORTS

收录：SCI-EXPANDED(收录号：WOS:000741362900005)、、Scopus(收录号：2-s2.0-85117457586)、WOS

基金：This study was supported by the National Natural Science Foundation of China [Grant Numbers 31472243, 31902314]; Natural Science Foundation of Guangdong Province, China [Grant Number: 2019A1515011142]; Shenzhen Projects for basic Research (JCYJ20190813142005766); and the Project of Enhancing School with Innovation of Guangdong Ocean University [Grant Number: GDOU230419057] and the Program for Scientific Research Start-Fund of Guangdong Ocean University [Grant Number: 101402/R17088].

语种：英文

外文摘要：Heat stress can significantly affect the immune function of the animal body. Heat stress stimulates oxidative stress in intestinal tissue and suppresses the immune responses of mice. The protecting effects of chitosan on heat stress induced colitis have not been reported. Therefore, the aim of this study was to investigate the protective effects of chitosan on immune function in heat stressed mice. Mice were exposed to heat stress (40 degrees C per day for 4 h) for 14 consecutive days. The mice (C57BL/ 6J), were randomly divided into three groups including: control group, heat stress, Chitosan group (LD: group 300 mg/kg/day, MD: 600 mg/kg/day, HD: 1000 mg/kg/day). The results showed that tissue histology was improved in chitosan groups than heat stress group. The current study showed that the mice with oral administration of chitosan groups had improved body performance as compared with the heat stress group. The results also showed that in chitosan treated groups the production of HSP70, TLR4, p65, TNF-alpha, and IL-10 was suppressed on day 1, 7, and 14 as compared to the heat stress group. In addition Claudin-2, and Occludin mRNA levels were upregulated in mice receiving chitosan on day 1, 7, and 14 of heat stress. Furthermore, the IL-6, IL-10, and TNF-alpha plasma levels were down-regulated on day 1, 7, and 14 of heat stress in mice receiving the oral administration of chitosan. In conclusion, the results showed that chitosan has an anti-inflammatory ability to tolerate hot environmental conditions.