文献类型：期刊文献

英文题名：Protective Effects of Bile Acids Against Hepatic Lipid Accumulation in Hybrid Grouper Fed a High-Lipid Diet

作者：Xu, Jia[1];Li, Xiaoyue[1];Yao, Xinzhou[1];Xie, Shiwei[1,2,3];Chi, Shuyan[1,2,3];Zhang, Shuang[1,2,3];Cao, Junming[1,2,3];Tan, Beiping[1,2,3]

机构：[1]Guangdong Ocean Univ, Lab Aquat Anim Nutr & Feed, Fisheries Coll, Zhanjiang, Peoples R China;[2]Aquat Anim Precis Nutr & High Efficiency Feed Eng, Zhanjiang, Peoples R China;[3]Minist Agr, Key Lab Aquat Livestock & Poultry Feed Sci & Tech, Zhanjiang, Peoples R China

年份：2022

卷号：9

外文期刊名：FRONTIERS IN NUTRITION

收录：SCI-EXPANDED(收录号：WOS:000752104800001)、、Scopus(收录号：2-s2.0-85124322217)、WOS

基金：This work was supported by the National Key R&D Program of China (2019YFD0900200), the National Natural Science Foundation of China (No. 31772864), the China Agriculture Research System of MOF and MARA (CARS-47), Science and Technology Project of Zhanjiang (2020A05003), and the Natural Science Foundation of Guangdong Province (2018A030313154 and 2020A1515011129).

语种：英文

外文关键词：high-fat diet; taurocholic acid; growth performance; lipid metabolism; fish

外文摘要：Bile acids (BAs) usually display growth-promoting and lipid-lowering properties when supplemented to the diet. The effects of a high-lipid diet (HD) and BAs supplementation on growth performance and lipid deposition of hybrid grouper (Epinephelus fuscoguttatus female x E. lanceolatus male) was evaluated in this study. Compared to the control diet (CD), the HD did not significantly affect the fish growth performance, but it promoted lipid deposition, as revealed by a significantly higher crude lipid content of the whole body, muscle, and liver. Among the HD supplemented with taurocholic acid (BD) groups, and compared to the HD, fish fed dietary supplementation of BAs at 900 mg kg(-1) exhibited the best growth performance and lowest hepatic lipid deposition. In most BD groups, the content of total cholesterol, low-density lipoprotein cholesterol, and triglycerides in serum, as well as the content of total cholesterol in the liver, were decreased, whereas the content of high-density lipoprotein cholesterol in serum was increased. In addition, the most strongly influenced pathways between the control, HD, and B3D groups were fatty acid biosynthesis, insulin signaling pathway, and AMPK signaling pathway. The improvement of lipid metabolism induced by the supplementation of BAs may be attributed to decreased expression of lipogenesis genes and proteins (enzymes), and increased lipolysis. In conclusion, dietary supplementation of BAs at 900 mg kg(-1) promoted growth performance and reduced lipid accumulation, whereas BAs supplementation improved the hepatic lipid metabolism by enhancing hepatic lipolysis, inhibiting lipogenesis, and regulating associated transcriptional factors in hybrid grouper.