文献类型：期刊文献

中文题名：近江牡蛎糖胺聚糖毒理学的初步评价

英文题名：Toxicological evaluation of glycosaminoglycan from Crassostrea Rivularis

作者：胡雪琼[1];吴红棉[1];范秀萍[1];蒋杨[1]

机构：[1]广东省水产品加工与安全重点实验室,广东普通高等学校水产品深加工重点实验室,国家贝类加工技术研发分中心(湛江),广东海洋大学食品科技学院,广东湛江524088

年份：2014

卷号：35

期号：8

起止页码：349

中文期刊名：食品工业科技

外文期刊名：Science and Technology of Food Industry

收录：CSTPCD、、北大核心2011、北大核心、CSCD、CSCD2013_2014

基金：广东省海洋渔业科技推广专项(A201008I02)

语种：中文

中文关键词：近江牡蛎;糖胺聚糖;毒理学

外文关键词：Crassostrea Rivularis; glycosaminoglycan; toxicology

中文摘要：目的:研究近江牡蛎糖胺聚糖作为保健食品使用的安全性。方法:采用急性毒性实验、遗传毒性实验(Ames实验、小鼠骨髓细胞微核实验、小鼠精子畸形实验)进行毒理学研究与评价。结果:小鼠经口最大耐受剂量(MTD)均大于20.0g/kg;3项遗传毒性实验的结果皆为阴性,未显示出致突变性。结论:近江牡蛎糖胺聚糖急性毒性分级属无毒级,无遗传毒性。

外文摘要：Objective：The toxicological safety of glycosaminoglycan from Crassostrea Rivularis（CG） as a healthy food material was evaluation. Methods：Acute toxicity test,genetic toxicity test（Ames test,micronucleus test of born marrow in mice,sperm shape abnormality test in mice） were used in this study according to the procedures for toxicological assessment of food. Results：Acute toxicity test showed that the acute oral maximum tolerated doses（MTD） of CG to male and female rats were both more than 20.0g/kg body weight. All results of three genotoxicity tests were negative and no mutagenicity. Conclusion：Glycosaminoglycan from Crassostrea Rivularis（CG） was non-toxic substances based on the acute toxicity grading and non-genetic toxicity based on genotoxicity tests.