文献类型：期刊文献

英文题名：Preliminary Report on Intestinal Flora Disorder, Faecal Short-Chain Fatty Acid Level Decline and Intestinal Mucosal Tissue Weakening Caused by Litchi Extract to Induce Systemic Inflammation in HFA Mice

作者：Sun, Dongfang[1];Wang, Chen[1];Sun, Lijun[1];Hu, Lianhua[1];Fang, Zhijia[1];Deng, Qi[1];Zhao, Jian[2];Gooneratne, Ravi[3]

机构：[1]Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China;[2]Univ New South Wales, Sch Chem Engn, Sydney, NSW 2052, Australia;[3]Lincoln Univ, Fac Agr & Life Sci, Dept Wine Food & Mol Biosci, Canterbury 7647, New Zealand

年份：2022

卷号：14

期号：4

外文期刊名：NUTRIENTS

收录：SCI-EXPANDED(收录号：WOS:000762310400001)、、Scopus(收录号：2-s2.0-85124370375)、WOS

基金：FundingThis work was supported by grants from the Guangdong Provincial Special Fund for Technological Innovation of Modern Agricultural Industry (No. 2019KJ151) and Guangdong Provincial key research and development program (2021B0202060001).

语种：英文

外文关键词：gut microbiota; systemic inflammation; litchi

外文摘要：Certain foods are known as "heating" foods in Chinese medicine. Over-consumption of these foods can lead to symptoms known as "heating up". These symptoms have been shown to be symptoms of systemic low-grade inflammation. However, the mechanism by which these foods cause inflammation is not clear. In this preliminary study, we investigated dysbacteriosis of the gut microbiota as a possible cause of inflammation by litchi, a typical "heating" food. A human flora-associated (HFA) mouse model (donor: n = 1) was constructed. After gavaging the mice with litchi extract suspension at low, medium and high doses (400, 800, 1600 mg/kg center dot d(-1), respectively) (n = 3) for 7 days, the serum levels of inflammatory cytokines, gut microbiota, the concentration of SCFAs and the integrity of the intestinal mucosal barrier were measured. The results revealed significant increases in the abundance of Prevotella and Bacteroides. A significant increase in the abundance of Bilophila and a decrease in Megasomonas was observed in the high-dose group. High-dose litchi intervention led to a decrease of most SCFA levels in the intestine. It also caused a more than two-fold increase in the serum TNF-alpha level and LPS level but a decrease in the IL-1 beta and IL-6 levels. Medium- and high-dose litchi intervention caused widening of the intestinal epithelial cell junction complex and general weakening of the intestinal mucosal barrier as well as reduced energy conversion efficiency of the gut microbiota. These data suggest that litchi, when consumed excessively, can lead to a low degree of systematic inflammation and this is linked to its ability to cause dysbacteriosis of the gut microbiota, decrease SCFAs and weaken the intestinal mucosal tissues.